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This multimodal death network underpins the adaptability and therapeutic resistance of PD neurodegeneration, necessitating combinatorial targeting for effective intervention

Thus, PG levels, which are known to protect the gastric mucosa by increasing blood flow, were not altered by NPW treatment, while blockade of COX enzymes reduced the PG levels

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Another feature of the recovery process is the removal of damaged mitochondria by a form of autophagy termed mitophagy84,85, and inhibition of mitophagy by lysosomal cholesterol accumulation was shown to sensitize mice to APAP hepatotoxicity86