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Cognitive decline often experienced as brain fog, difficulty concentrating, or reduced mental sharpness has multiple biological drivers that peptides can address

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Participants were excluded if they were being actively treated for sleep disorders, self-reported illicit substance usage, reported excessive consumption of alcohol or caffeine, had major or unstable psychiatric disorders or cognitive impairment as evaluated by the sleep physician/psychologist, were shift-workers, had transmeridian travel in the past 2 months (two or more time zones traversed) or were pregnant or lactating

To quantify the synaptic territory of apical dendrites, we calculated the area of each arbor along the retinotopic axes using maximum projections of image subvolumes containing a single PyrN arbor (Figure 6C-D