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The increasing prevalence of conditions such as ADHD has paralleled the increase in diet-related health issues, with exposure to nutritional factors during or even prior to pregnancy being important [174]

Wang et al., 2004

90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

86-88 Interestingly, individuals with depression also appear to have a greater likelihood of developing chronic pain syndromes, suggesting bi-directionality due to a common mechanism, possibly rooted in chronic or extreme stress and reduced neuroplasticity