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Because vitamin B12 is found primarily in animal products, people who follow vegetarian or vegan diets are at increased risk of deficiency, says Lauren Manaker, a registered dietitian and owner of Nutrition Now Counseling

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However, a Phase 2 clinical study evaluating ANS-6637 in treatment-seeking adults was terminated early due to concerns of liver toxicity (307), and efficacy results for a clinical trial using a hepatic ALDH2 mRNA inhibitor (DCR-AUD) are not yet publicly available (NCT05845398)