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Rosiglitazone suppresses renal crystal deposition by ameliorating tubular injury resulted from oxidative stress and inflammatory response via promoting the Nrf2/HO-1 pathway and shifting macrophage polarization

Bryer and Goldfarb observed that a 2-week vitamin C supplementation regimen in healthy males, followed by 4 days of eccentric exercise increased the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio, thereby preventing exercise-induced oxidative stress compared to the placebo group [29]

doi: 10.1016/j.bbrc.2019.05.156 15 ChenJ.ZhangD

For years intravenous glutathione injections have been clinically recognized for their therapeutic value in treating acute poisoning and chronic liver disease