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Dysregulation of this pathway through altered dimerization, post-translational modifications, or impaired regulation contributes to the pathophysiology of Alzheimers disease, Parkinsons disease, Huntingtons disease, and amyotrophic lateral sclerosis, leading to protein aggregation, mitochondrial dysfunction, and neuroinflammation

By improving the solubility, stability, bioavailability, and delivery of selected phytochemicals, nanoformulations may help address some pharmacokinetic limitations of conventional phytochemical approaches

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