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Similarly, turtle-derived peptides and their functional derivatives significantly reduced colonic inflammation by 4060%, restored tight-junction protein levels, and rebalanced gut-microbiota composition toward a youthful, anti-inflammatory profile [167]

doi: 10.1002/ptr.4796 22

Furthermore, this approach utilised chitosan coating for TPP + , which has a higher biocompatibility, biodegradability, and enhances the stability of the nanocarriers while maintaining mitochondrial targeting properties [ + -functionalised MSNs for delivering -Tocopheryl succinate (-TOS), an effective therapeutical mitochondrial agent that induces apoptosis, which focused on using TPP + as a targeting ligand as well as -TOS to achieve good targeting efficiency [ + as a targeting ligand has also been reported as a DDS for DOX, where TPP + provided the targeting properties and DOX presented the anti-cancerous effects [ + -modified MSNs

Liang Z, He H, Zhang B, Kai Z, Zong L