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8 To continue clinical trials, preclinical data including the efficacy, toxicity, and pharmacokinetics of panduratin A are necessary

[DOI] [PMC free article] [PubMed] [Google Scholar] 206.Franzoni F., Scarfo G., Guidotti S., Fusi J., Asomov M., Pruneti C

Overexpression of SIRT3 decreases HCC cell proliferation and promotes apoptosis through multiple mechanisms, including the activation of the GSK-3/Bax signalling pathway [196], upregulation of p53 [198], and reduction in Mdm2-mediated p53 degradation [199]