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This syndrome is characterized by clinical symptoms of sickness behavior such as leaden paralysis of the limbs, hypersomnia, and hyperphagia/weight gain, while mood reactivity is unimpaired, i.e., mood brightens in response to positive events (according to DSM-5 criteria for MDD with atypical features), while still suffering from lack of concentration and higher levels of exhaustibility as in melancholic MDD [99]

doi: 10.1128/JVI.75.12.5703-5710.2001

The following three major factors govern the fluidity of the plasma membrane: The degree of saturation and length of the fatty acid chains Temperature Cholesterol concentration Because fully saturated fatty acid chains have no kinks, they can pack together very tightly, decreasing membrane fluidity

in addition, loss of nhr-49 sensitizes worms to arsenite and paraquat (Horikawa and Sakamoto, 2009