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However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)

Wet age-related macular degeneration (AMD) mainly affects the macula

These latter will lead in turn to the recruitment of more neutrophils and macrophages, perpetuating a vicious cycle of endogenous oxidant production

One alternative therapy that some patients consider is hyperbaric oxygen therapy (HBOT)