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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

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In particular, the selection of an appropriate control or comparison group is required to determine, all other things being equal, whether a treatment is efficacious for a given illness, whether it has benefits over other therapies for the illness, and how it can achieve its effects