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Shallow trophoblast invasion in this syndrome causes maternal endothelial cell dysfunction and hypoxia in the developing fetus

Ultimately, more research studies with larger sample sizes will need to be conducted before more conclusive claims can be made about the role, if any, of MTHFR variants in disease

Given the documented risks associated with high-dose or long-term use of flavonoids, including hepatotoxicity, genotoxicity, endocrine disruption, gut microbiota dysbiosis, and drug interactions, it is imperative to develop optimized oral and topical delivery strategies