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This could be daily, weekly, monthly, or at other intervals appropriate for your physiology
It represents real science about when the peptide begins losing its ability to do what you are paying it to do
Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)
Three, B12 supplementation is used, and the optimal frequency of administration is established in order to stay symptom-free
