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Supplementary Video 3)
Reactive oxygen species mainly include O 2 .- and H 2 O 2 , which are physiologically generated as by-products of mitochondrial electron transfer
There are many external factors contributing to hepatocellular injury, including insulin resistance (65), adipokine dysregulation (66), hepatic ATP depletion (67), uric acid-induced hepatocyte mitochondrial dysfunction (68), and the effects of intestinal microbiota products (69)
