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4c, d, Fig
The caveat is that the phrase five years ago is interpretive
3.3(b), from day 14 onwards, the group treated with 100 nM of OKA spent significantly less time in the tank's upper half than the control group

Previous studies have revealed that alterations in the mechanisms directing tumor development may initiate or interfere with immune responses in the TME, leading to either immune resistance or dysfunction, and eventually resulting in the tumor's avoidance of the immune system