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What the Clinical Data Shows In Phase IIb clinical trials, participants taking 1 mg of AOD-9604 daily alongside diet and exercise lost an average of about 6 lbs over 12 weeks, compared to under 2 lbs in the placebo group with the peptide directly stimulating fat breakdown and inhibiting new fat storage, and without raising IGF-1 or disrupting glucose. John Comandari, Beyond Stem Cells Notice what that data tells us: the effect is real but modest , and it works best alongside diet and exercise, not as a replacement for them