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In the TCA cycle, ISCs are crucial cofactors for three enzymes, aconitase, succinate dehydrogenase (SDH), and fumarase (Fig
doi: 10.3390/ijms231810406 123 TarantinoG.CitroV
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ACSL4 and lysophosphatidylcholine acyltransferase 3 (LPCAT3) facilitate PUFA incorporation into membrane phospholipids [40], while lipoxygenases (LOXs), such as ALOX5 and ALOX15, catalyze the formation of LOOHs, triggering ferroptosis [41] (Fig
