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doi:10.1093/ajcn/80.6.1551 Funk RS, Jones J, Polireddy K, et al
2017;26(3):50922.e6

As a molecule naturally occurring in the human body declining with age rather than foreign to our biology it rarely produces adverse reactions at the concentrations used in cosmetic formulations

NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor
