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By binding to CD80 and CD86 receptors on APC and obstructing the costimulatory effects of the T cell surface molecule CD28, activation of CD8 + T cells and the release of inflammatory cytokines linked to AA, namely IL2, TNF, and IFN, are both efficiently inhibited by abatacept [226]

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Collectively, these observations suggest that -cell heterogeneity may shape not only the functional responsiveness to incretins but also the overall efficacy of microbiota-targeted interventions aimed at supporting -cell function

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