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To avoid protein accumulation, ATF4 will activate reticulophagy by facilitating the interaction between ER surface proteins like CCPG1 and ATF8

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The prevalence of AMD is estimated to be 8.69% in the global population between 4585 years of age, affecting approximately 200 million individuals in 2020, rising to more than 288 million people by 2040, due to population aging (1)

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Biosci Trends (2019) 13(2):1529

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