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: Activation

Indeed, compound Z30702029 inhibited GSDME-N-terminal domain-mediated pyroptosis in preclinical experiments (127)

doi: 10.15252/embr.202152972 79 Van BambekeF.Barcia-MacayM.LemaireS.TulkensP

However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs