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This study was conducted with reference to a previous investigation on the reproductive toxicity of PS-MPs in male mice, in which the administered dose of PS-MPs was 1 mg/day (equivalent to 33.340 mg/kg/day for mice weighing 2530 g) [40]
doi: 10.1016/j.fertnstert.2013.01.111
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Further chemical proteomics investigations have demonstrated that A16 specifically targets GPX4 under both in situ and in vivo conditions, inducing ferroptosis
