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Mechanistically, Arctigenin downregulated CPT1-mediated FAO, which further inhibited nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome assemblies in macrophages (Qiao et al., 2020)

The P2X7 purinergic receptors belong to one of the P2X ion channel receptor family members that have been suggested to mediate pain and inflammation in OA (Chow and Chin 2020)

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Concentrations of l-carnitine, BB, and TMA were determined by stable isotope dilution LC-MS/MS
