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We previously reported that IL-13 increases intracellular 15-HpETE-PE via 15LO1 in vitro in modest molar amounts (see also Supplemental Figure 4A and ref

81 Furthermore, the signaling pathways that regulate the cellular response to mechanical stress are critical for maintaining ACL integrity

It is evident in whole-animal studies where the underlying cellular and molecular mechanisms are difficult to resolve, and it is often studied in isolated tissues where tolerance can be measured as a rightward shift in the dose-response curve that may also be associated with a reduction in the maximum response