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Serious but rare complications: Hypokalaemia: Rapid B12 replacement in severely deficient patients can precipitate potassium depletion during haematopoietic recovery, potentially causing cardiac arrhythmias

The 2 circled hydrogens are lost and replaced by double bonds when ascorbic acid is oxidized to dehydroascorbic acid

CONCLUSION: These results indicate that repeated administration of hydroxocobalamin was devoid of significant diaphragmatic and cardiac muscle toxicity and therefore remains a safe antidote for acute cyanide poisoning

Notably, it was observed that there are no differences between the repair capacity of both UV and cisplatin induced lesions in A549 and NCI H23 cells, the most and least resistant cells, respectively (Fig