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One RCT did not find significant effects of melatonin on the average benzodiazepine dosage, benzodiazepine cessation proportion, or withdrawal symptoms at 24 weeks [100]
Accordingly, TRZ, a drug with a multi-modal mechanism of action, approved for the treatment of depression in several countries, is suggested as an alternative treatment for pain relief by the NICE Clinical Guideline Neuropathic pain Pharmacological Management [7]
Doug Ross in the NBC medical drama ER (19941999), for which he received two Primetime Emmy Award nominations
