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Reactive astrocytes might be also involved the neuroinflammation and the BBB dysfunction, as observed in multiple sclerosis and experimental autoimmune encephalomyelitis [117, 118]
Nitric oxide (NO) appears to play a major role in the viability of pericytes when exposed to MGO since iNOS inhibition improved cell viability without changing NF-B DNA binding activity [96]
doi: 10.1016/j.redox.2025.103590
The Cas9/sgRNA ribonucleoprotein complex, while the most responsive mode of action, has a low off-target rate and low toxicity, but the large size of the complex complicates delivery
