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Adipose tissue regulates metabolism by responding to signaling molecules, such as adipokines produced by other metabolic tissues (for example by crosstalk between the liver and skeletal muscle) [46]

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The body is essentially in a constant state of tissue remodeling

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the role of TLR4/NF-B/NLRP3/Caspase-1 signaling pathway

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From these proteins, 24 have been shown to bind to the IGF-1R promoter only in MCF7 cells, whereas 19 only in C4.12.5 cells (ER-negative) and even those that are ubiquitous have been found to be expressed in different levels within these cells

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