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Who should avoid it entirely

In addition to copper, an ion of Zn++ is also bound by the enzyme and likely plays a role in the catalysis

Enhanced oxidative or electrophilic stress may activate protein kinases able to phosphorylate NRF2 in the cytoplasm which then migrates into the nucleus and interacts with antioxidant response element

NAD+ is derived from vitamin B3 or niacin and is essential for cells to generate energy
