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Due to this, in the past few decades, several investigators have shown a strong research interest in understanding the molecular mechanisms of action of curcumin and its additional beneficial effects in preventing various complications

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63 The expression of MTHFD2 is closely related to the response of the folate antagonist methotrexate (MTX) and the thymidylate synthase inhibitor pemetrexed

However, although A with 42 amino acid residues (A (1-42) ) is available in low quantities, it is highly prone to aggregation and readily self-assembles to form a heterogenous mixture of oligomers and PF subsequently deposited as fibrils in senile plaques [160, 161]