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Unlike traditional weight loss medications, Tirzepatide is a dual GIP and GLP-1 receptor agonist , meaning it targets two powerful hormonal pathways that control appetite, digestion, and blood sugar

In fact, it has been validated the intrathecal delivery of a trivalent EPHA2, interleukin 13 receptor 2, besides HER2, CAR-T cell against primary, metastatic and recurrent group 3 MB xenografts in mouse models

Proven alternatives deliver comparable results with established safety: tirzepatide monotherapy produces 15-22% weight loss with FDA approval and extensive clinical data, while CagriSema (cagrilintide + semaglutide) delivers 15-25% weight loss with Phase 3 trial validation and clearer path to medical acceptance

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