glutathione in fungicide Frontiers Phase II - Glutathione Conjugation

doi: 10.3389/fonc.2021.610303 35 RothlinCVGhoshS

Under these conditions, the compound internalizes selectively Mrp2 without affecting Bsep, by a mechanism probably involving Ca2+-depending activation of inducible nitric oxide (NO) synthase (iNOS), followed by NO-mediated cGMP increase, and further cGMP-activated nPKC.113 However, higher ethacrynic acid doses, which can activate cPKC isoforms as well, induce internalization of both Bsep and Mrp2.113 As summarized in Figure 2, a picture is emerging to understand the effect of acutely-induced oxidative stress on the hepatobiliary function

(2009) Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

The role of astaxanthin as a nutraceutical in health and age-related conditions