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Shu G, Chen M, Liao W, Fu L, Lin M, Gui C, et al
This severe metabolic inflexibility directly contributes to the debilitating phenomenon of post-exertional malaise (PEM), where patients experience a massive, multi-day crash in symptoms following minor physical or cognitive exertion, effectively trapping them in a cycle of energy debt
Semaglutide is designed to act like this hormone for longer, which is why it is given as a once-weekly injection
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