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However, morphological studies have demonstrated that cochlear development proceeds normally, and the gross morphology of the organ of Corti is normal, indicating that Lgr5 is dispensable for hair cell formation (Chai et al., Lgr5 -positive cells in the postmitotic neonatal cochlea that have garnered attention recently as a possible source of hair cell progenitors

According to one study, only cells that had lost MDM2 gene functionality underwent senescence [86]

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