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Description
The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation
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Simultaneously, the preservation of SAM levels maintains cellular methylation capacity for essential epigenetic modifications and protein functions

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition
