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Advanced glycation end-products (AGE) are the result of non-enzymatic addition of glucose or other saccharides to proteins, lipids, and nucleotides
Therefore, ERGO may suppress the kynurenine pathway possibly via suppressing the CXCL9-induced activation of IDO
and inhibiting lipopolysaccharide-induced NF-B p65 translocation and mitogen-activated protein kinase phosphorylation in dendritic cells, thereby reducing inflammation [125, 228]

Accepted: June 22, 2013
