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Interestingly, B12 did not affect the intracellular protein levels of IL-1B in the cultures of the SEV group, and, regardless of the treatment, the intracellular protein levels of IL-1B were very low, close to or below the detection limit of the method ( Figure 3F )

Life Sci 248:117474

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Signs include: constipation/ diarrhea fatigue hallucinations red tongue rough skin Since B3 is so integral to the health of the digestive system, a lot of the symptoms revolve around the intestines
