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Specifically, robust evidence from large-scale, multicenter randomized controlled trials is still needed to conclusively establish efficacy, determine optimal dosing and timing strategies, and fully evaluate safety before widespread clinical adoption in RDS management can be recommended

The metabolites associated with glycolysis, tricarboxylic acid cycle (TCA cycle), and urea cycle, as well as amino acids and coenzymes did not exhibit clear changes indicating activated metabolic pathways (Fig

Moreover, we found that colistin-induced depolarization is sensitive to cyclosporin A, a potent inhibitor of mitochondrial cyclophilin D (CyPD), one of the components of the mPTP, whose expression and function are required for the onset of the permeability transition 49

Same principles apply