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Only mature metaphase II (MII) oocytes that were denuded of surrounding cumulus cells were selected for the study

[DOI] [PubMed] [Google Scholar] 38.Kroll M., Arenzana-Seisdedos F., Bachelerie F., Thomas D., Friguet B., Conconi M

(e) External factors (e.g., diet, antibiotic use, chronic infections, etc.) may also alter the composition and behavior of cancer-associated bacteria

The cause is a restriction of the activity of cytochrome P450 CYP3A4 in the CYP enzyme system in the liver induced by pro-inflammatory cytokines (e.g., IL-6, TNF-, and IL-1Ra), an effect that is stronger at high concentrations of these cytokines (i.e., during highly perturbated and excessive inflammatory events) [18,19,20,21]
