n4-sulfone-sulfamethoxazole-glutathione conjugate Mechanism of the glutathione conjugation to the CDNB. Step 1: SulfaMethoxazole N4-glucoside 119691-75-7 wiki
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Journal of the American College of Nutrition, 39 (6), 547556

Vitamin E in dermatology, Pubmed

The intestinal mucosa is constantly exposed to oxidants and carcinogens taken in from diet and/or bacteria, whose chronic exposure may cause production of free radicals leading to redox imbalance and subsequent DNA damage, disturbing the intestinal metabolic equilibrium (73)

This results in your body burning through its Glutathione - with the result that toxic by-products linger, and your hangover feels worse, for longer 27