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SAM and SAH compete for binding to MTHFR, so the SAM:SAH ratio is an important determinant of MTHFR activity within cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Yu D, et al

But you should always inform your healthcare provider about all medications and supplements you're using

Its a naturally occurring antioxidant thats pivotal in the skin whitening process
