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Two of the SOD isoforms are located within cells, whereas the third SOD isoform is found in the extracellular space (385)

The metabolic profiles were augmented via a Monte Carlo-driven uncertainty propagation procedure (see Methods Estimation of Metabolic Profiles), in which each measurement was perturbed K pert times based on its estimated variance (Cramr-Rao lower bounds issued by the LCModel metabolite quantification maps, shown in Supplementary Fig

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This observation supports the hypothesis that ferroptosis, a type of nonapoptotic cell death, has a greater possibility of inducing inflammation than apoptosis