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Description
In regions of high metabolic activity, such as in the brain, oxidative stress is more likely due to the increased production of free radicals, namely the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)

Phenylpropanolamine and the risk of hemorrhagic stroke

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The documented pattern is simply a steady daily presence of the inhibitor, held long enough for the downstream metabolic change to accumulate
