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Parts from both kidneys were homogenized (MPW-120 homogenizer, Med instruments, Poland) to obtain 20% homogenate that was stored overnight at -20 C

MSD PK data was further analyzed in order to identify privileged functional groups that are observed in increased propensity in low in vivo CL u ( in vivo CL u values that are less than mean minus two standard deviations) and long half-life (rat t half_eff greater than 2 h) compounds with low extraction ratios

The brain cells, including neurons, oligodendrocytes, astrocytes, and microglia, use the EVs for vital communication that affects synaptic connections, neural growth, and cell differentiation (134)

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