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Cancer cells can hijack the activities of osteoblasts and promote osteoclastogenesis to boost their proliferation and establish a vicious cycle among osteoblasts, osteoclasts, and transformed cells, since such a bone resorption process is accompanied with the release of numerous factors from the bone matrix such as cytokines, calcium, collagens, growth factors, glycoproteins, hyaluronans, proteoglycans, and proteinases [75, 76]

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