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Thus, the doseresponse of H 2 S can explain its variable effects reported in literature

Riyazuddin R, Bela K, Horvth E, Rig G, Gall A, Szabados L, Fehr A, Csiszr J (2019) Overexpression of the Arabidopsis glutathione peroxidase-like 5 gene (AtGPXL5) resulted in altered plant development and redox status

Chondrocytes, the only cellular component of cartilage, maintain the dynamic equilibrium of the extracellular matrix (ECM) through precise regulation of collagen type II and matrix-degrading enzyme secretion ( In mouse models of OA, typical characteristics of ferroptosis have been observed in chondrocytes, including abnormal iron metabolism, lipid peroxidation, and mitochondrial dysfunction (Yao et al., 2021)