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Its role in the repairing of nerve and cell damage caused by free radicals explains why its also referred to as the master antioxidant It is difficult to maintain healthy levels of glutathione through supplements, as it is mainly produced in the body The production of glutathione decreases with age

These mechanistic sites include neuronal hyperexcitability, A and/or tau protein misfolding/oligomerization, neuroinflammation, reactive oxygen species (ROS) production, and metal dyshomeostasis (Figure 1)

(PubMed) Sawada T, Yokoi K

Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages