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KD of target genes by shRNAs was done as described previously (65)

Furthermore, the authors of this study state that telomerase activity was found to be maximal when the ratio of reduced/oxidized glutathione was high.69 A study with elderly humans revealed that higher glutathione levels are associated with a lower incidence of illnesses and higher levels of self-rated health, which is what would be expected if elevated glutathione levels are increasing telomerase activity and lengthening telomeres.70 Because glutathione deficiency is associated with increased risks to chronic degenerative diseases and increased glutathione levels are associated with better health and increased longevity, it has been suggested that glutathione blood levels may be an effective and reliable marker of physiological/functional aging.70 Conclusion The body of research that has been reviewed in this article shows clearly that higher glutathione levels are associated with better health and life extension