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It is frequently observed that environmental exposures are associated with the etiology of disease, whereby they interact with or induce DNA mutations and epigenetic alterations
Furthermore, irisin, functioning as an exercise mimetic, plays a pivotal role in the regulation of gut metabolism
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Collectively, existing research shows that GSK-3 is a key node related to aging and aging-related diseases, particularly in terms of the regulatory network centered on the GSK-3 /Nrf2 axis
