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Although functional data supporting a trans- inhibition model were obtained when constitutive activation of JAK2 was shown with a JAK2 construct where the pseudokinase and KDs were swapped and this construct showed significant cytokine-independent activation only in the presence of wild-type JAK2 (51)
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Specifically, knocking out NCOA4 in cardiomyocytes alleviates heart failure caused by transection aortic contraction (TAC) by inhibiting ferritinophagy, free iron overload, and increased lipid peroxidation

These mechanisms hold significant importance in diseases such as osteoporosis, atherosclerosis, and post-traumatic bone repair, and targeting these cells (e.g., inhibiting mast cells) may ameliorate the dysregulation of the bone-vascular axis (88, 89)

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